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Name of Media:

Long-term developmental effects of withholding parenteral nutrition for 1 week in the paediatric intensive care unit: a 2-year follow-up of the PEPaNIC international, randomised, controlled trial


Sören Verstraete, MD; Sascha C Verbruggen, MD; José A Hordijk, MPsych; Ilse Vanhorebeek, PhD; Karolijn Dulfer, PhD; Fabian Güiza, PhD; Esther van Puffelen, MD; An Jacobs, MD; Sandra Leys, MPsych; Astrid Durt, MSc; Hanna Van Cleemput, MPsych; Renate D Eveleens, MD; Gonzalo Garcia Guerra, MD; Pieter J Wouters, MSc; Koen F Joosten, MD; Prof Greet Van den Berghe, MD

Publisher or Source:

The Lancet

Type of Media:

Medical Journal

Media Originally for:

Critical Care Physicians, Nurses and/or Other Critical Care Medical Professionals

Country of Origin:


Primary Focus of Media:

Pre-Use of PICS Designation

COVID-19 Related:



The paediatric early versus late parenteral nutrition in critical illness (PEPaNIC) multicentre, randomised, controlled trial showed that, compared with early parenteral nutrition, withholding supplemental parenteral nutrition for 1 week in the paediatric intensive care unit (PICU; late parenteral nutrition) reduced infections and accelerated recovery from critical illness in children. We aimed to investigate the long-term impact on physical and neurocognitive development of early versus late parenteral nutrition.

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