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Name of Media:

Cost-minimisation analysis of sivelestat for acute lung injury associated with systemic inflammatory response syndrome


Naoki Aikawa, Seitaro Fujishima, Makoto Kobayashi, Shozo Matsuoka and Taira Abiru

Publisher or Source:


Type of Media:

Medical Journal

Media Originally for:

Critical Care Physicians

Country of Origin:


Primary Focus of Media:

Pre-Use of PICS Designation

COVID-19 Related:



Objectives: To conduct a cost-minimisation analysis of sivelestat sodium hydrate treatment for patients in the intensive care unit (ICU) with acute lung injury (ALI) associated with systemic inflammatory response syndrome (SIRS) caused by infection.

Design: The analysis was performed based on data from a phase III randomised, multicentre, double-blind, controlled clinical study of up to 14 days treatment with sivelestat, in which the effect of intravenous sivelestat at a high dose (0.20 mg/kg/h; the sivelestat group) was compared with that at a low dose (0.004 mg/kg/h, effectively a placebo; the control group).

Patients: Patients with ALI associated with SIRS caused by infection, who began their treatment under mechanical ventilation management in the ICU.

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