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Long-term developmental effects of withholding parenteral nutrition for 1 week in the paediatric intensive care unit: a 2-year follow-up of the PEPaNIC international, randomised, controlled trial
Sören Verstraete, MD; Sascha C Verbruggen, MD; José A Hordijk, MPsych; Ilse Vanhorebeek, PhD; Karolijn Dulfer, PhD; Fabian Güiza, PhD; Esther van Puffelen, MD; An Jacobs, MD; Sandra Leys, MPsych; Astrid Durt, MSc; Hanna Van Cleemput, MPsych; Renate D Eveleens, MD; Gonzalo Garcia Guerra, MD; Pieter J Wouters, MSc; Koen F Joosten, MD; Prof Greet Van den Berghe, MD
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Type of Media:
Media Originally for:
Critical Care Physicians, Nurses and/or Other Critical Care Medical Professionals
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Primary Focus of Media:
Pre-Use of PICS Designation
The pediatric early versus late parenteral nutrition in critical illness (PEPaNIC) multicenter, randomized, controlled trial showed that, compared with early parenteral nutrition, withholding supplemental parenteral nutrition for 1 week in the pediatric intensive care unit (PICU; late parenteral nutrition) reduced infections and accelerated recovery from critical illness in children. We aimed to investigate the long-term impact on physical and neurocognitive development of early versus late parenteral nutrition.
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