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Name of Media:

It’s Not All in the Genes

Author(s):

Bernstein CN and Sargent M

Publisher or Source:

The American Journal of Gastroenterology

Type of Media:

Medical Journal

Media Originally for:

General Medical Professionals

Country of Origin:

United States

Primary Focus of Media:

Pre-Use of PICS Designation

COVID-19 Related:

No

Description:

It has long been known that patients with inflammatory bowel disease (IBD) are at higher risk of systemic thromboembolism than is the general population. In fact, patients with both ulcerative colitis (UC) and Crohn’s disease (CD) have a 3- to 4-fold higher number of thromboembolic events including pulmonary embolism and a 6-fold higher incidence found at autopsy. It has been hypothesized that prothrombotic genetic variants may be more prevalent in IBD patients than in the general population.

Bernstein et al identified 492 IBD patients from the Manitoba IBD Research Registry and 412 controls from Manitoba Health’s administrative database. Subjects filled out questionnaires and their records were reviewed to determine their demographics, diagnosis, environmental factors, family history, smoking history, IBD phenotype, and extent and location of disease. All participants donated blood for genetic analysis, and most were contacted 2 years after venipuncture to update their history of thromboembolic events. Subjects’ blood was analyzed for the 4 most common genetic mutations associated with the risk of thrombosis.

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