VIEW SELECTED LIBRARY MEDIA

Original_edited.jpg

Name of Media:

Decontamination of the mouth or digestive tract was not linked to reductions in drug-resistant bloodstream infections in the intensive care unit

Author(s):

the University of Southampton and Bazian

Publisher or Source:

NIHR Dissemination Centre

Type of Media:

Medical Professional Education

Media Originally for:

Critical Care Physicians

Country of Origin:

United Kingdom of Great Britain and Northern Ireland (the)

Primary Focus of Media:

Pre-Use of PICS Designation

COVID-19 Related:

No

Description:

Decontamination strategies to remove potentially harmful bacteria from the mouth, throat and gut of critically ill patients don’t reduce the risk of intensive care unit-acquired bloodstream infections or deaths from bacteria that were resistant to antibiotics. The study was carried out in 13 intensive care units across Europe, including the UK, with moderate to high levels of antibiotic resistance (extended resistance in more than 5% of all bloodstream infections). This fills an important gap in the evidence as most previous studies have been in units with lower levels of resistant organisms.

Infections with multi-drug resistant gram-negative bacteria are a frequent problem for ventilated patients on intensive care wards. In this trial of 8,665 patients, the use of chlorhexidine mouthwash, selective digestive tract decontamination, or selective mouth and throat decontamination were compared to standard care, involving daily body washings with chlorhexidine and a hand hygiene improvement programme.

The decontamination strategies were not associated with a significant difference in multi-drug resistant bloodstream infections, suggesting that they should not be used in the UK as a strategy to reduce antibiotic resistance in hospitals with similar extended resistance rates.

To view the attached Video media file, Click Icon:

PostICU, Inc's library staff reviewed this copyrighted material contained in the library and reasonably believes that its inclusion in our library complies with the "Fair Use Doctrine" because: (1) our library's is for nonprofit and educational purposes; (2) the nature of the copyrighted work is related to our mission; (3) the amount and substantiality of the portion used in relation to the copyrighted work as a whole is fair and reasonable; and (4) the potential market for or value of the copyrighted work will if impacted, should be enhanced, by its presence in our library.